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It works better for searching, it works offline, catch-all addresses just work with correct from address when replying, backup and archiving, can move mails from box to box without sending.
I also use roundcube, but only to read mails. If I want to reply to a catch-all mail I have to create an alias which is super tedious.
Mozilla used to have Sunbird, until they also rolled it into Thunderbird. Standalone calendars aren’t popular anymore, but in sure there’s some around.
I understand the mail integration, as appointments can be processed directly.